Dr. Sean Breen

Anti-Aging, Functional and Regenerative Medicine Specialist

Dr. Sean Breen is a graduate of the New York College of Osteopathic Medicine in Old Westbury, NY. Following medical school he was awarded a United States Navy Health Professions Scholarship and completed his post-graduate training at the prestigious Naval Medical Center located in San Diego, California. During his 9-year career as a Navy medical officer, he spent 4 years as a battalion surgeon with 1st Marine Division at Camp Pendleton, California.

In 2003, he deployed to Iraq in support of Operation Iraqi Freedom (OIF-1) as the battalion surgeon for 1st Battalion 4th Marines. He was in charge of 65 Navy Corpsman and responsible for the health of over 1,000 United States Marines. During his 9-month deployment, he was embedded with the Marines on the front lines directly in combat.

He was awarded a Navy and Marine Corps Achievement Medal with Valor for his actions on April 8, 2003, taking care of a fallen Marine in a section in Baghdad called Saddam City. Upon returning from combat in September 2003, he continued to serve with the Marine Corps as the battalion surgeon for 1st Combat Engineer Battalion and was promoted to be the 11th Marines Regimental Surgeon.

He was honorably discharged from the Navy in 2006 after being promoted to the rank of Lieutenant Commander.

Following his decorated military career, Dr. Breen shifted his focus to preventative medicine. Already proficient in osteopathic and CranioSacral manipulation, he went on to earn a degree in Medical Acupuncture from the Helms Medical Institute at the David Geffen UCLA School of Medicine. He completed the advanced fellowship with the American Academy of Anti-Aging and earned his board certification in Anti-Aging, Functional and Regenerative Medicine.

In addition, he became an expert in Bioidentical Hormone Therapy after training with Dr. Neal Rouzier, who is world renowned for his work and research in natural hormone replacement therapy. He is currently completing a Masters Degree in Metabolic and Nutritional Medicine at the University of South Florida medical school.

Dr. Breen is the founder and medical director for Dr. Sean Breen, PC. His clinic is the premier medical clinic in preventative, functional and regenerative medicine in Southern California.

His goal is to restore optimal health and prevent disease before it becomes symptomatic. He has developed an annual health plan that walks patients step-by-step through the healing process over an entire year.

Each patient receives a customized health plan designed to restore the body’s natural hormones to levels they had when they were 20 years old.

In addition, each patient receives a customized nutrition plan based on their specific physiology, biochemistry, and nutritional status. Lastly, he uses the latest scientific technology based on peer reviewed medical literature to help patients break free of the current medical model which is treating symptoms with drugs while failing to address the underlying or root cause of the disease.

In addition, Dr. Breen played Division-1A baseball as a pitcher for Iona College located in New Rochelle, NY (picture). He was a First Team academic All-American in his junior and senior years and was a NY State College All-Star in 1996. He was also named team captain in his senior year. His passion for athletics continues and he has been an active member of the CrossFit community since 2009. He is passionate about helping athletes achieve peak performance by avoiding overtraining and identifying injury depletion.

Personally, Dr. Breen has been married Erin since 2009 and has three children (Jack 7, Landon 4, and Danielle born October 29, 2017) and currently resides in the city of San Clemente, CA.




Zachary Lott, NP-BC

Anti-Aging, Functional and Regenerative Medicine Specialist

Zachary Lott is the cardiometabolic disease prevention specialist at the Breen Center for Optimal Health. He is licensed as a Nurse Practitioner and in Public Health. He is board-certified by the American Nurses Credentialing Center in Adult-Gerontolgy Acute Care. He holds a Master of Science Degree in Nursing and a Nurse Practitioner Master’s Certificate from California State University, Long Beach. He received his acute care training at the Keck Medical Center of USC and the MemorialCare Long Beach Medical Center. He is a member of the American Heart Association Council on Lifestyle and Cardiometabolic Health and the National Lipid Association. He holds certifications as a provider of the BaleDoneen Method and by the Academy of Preventative and Innovative Medicine.

Zachary’s post-graduate education includes a fellowship in functional, anti-aging, and regenerative medicine with Sean Breen, DO. He was trained in advanced bio-identical hormone replacement therapy by Neal Rouzier, M.D. and trained in heart attack, stroke, and diabetes prevention by Brad Bale, M.D. and Amy Doneen, DNP.

Zachary has a background in adult critical care, working at the bedside of the sickest and most unstable patients in the hospital. He was motivated by his critical care experience to find a treatment approach that prevents any person under his care from becoming as sick as those he saw in the intensive care unit.

​Zachary prevents and treats disease with an integrative approach to holistic care. He understands the importance of diet, exercise, sleep, and hormones in the role of the aging process and in the prevention of disease. Through his approach to wellness, he individualizes treatment to each person under his care with the use of specialized diagnostics, lifestyle management, genetic testing, and both allopathic and complimentary medicine. Along with helping people achieve their individual health goals, he aims to give them back their health and their life.

Zachary is a decorated Marine Corps veteran who completed his service in the Fleet Marine Force with Bravo Company, 1st Battalion, 4th Marine Regiment. He was awarded the Bronze Star Medal for valor for his actions in combat in 2003 during Operation Iraqi Freedom. His military career also included two overseas deployments, numerous personal and unit awards, and of multiple specialized training courses. Zachary gives back to the military community by doing pro bono work for disabled military veterans.

Zachary has a passion for disease prevention and has a personal vendetta against cardiovascular disease. This passion is driven by the toll that this disease takes on both the average American, what he sees as a public health crisis; and his own family, because of a disease called familial hyperlipidemia. His learning and research interests include lipidology, point-of-care ultrasound, and sleep. He has has a love for both learning and education and guest lectures at a number of local universities and private events.